Protein Details: Potassium voltage-gated channel subfamily A member 10

Protein ID

ICDB_Pro_0846

Protein Name

Potassium voltage-gated channel subfamily A member 10

Gene Name

KCNA10

Organism

Homo sapiens (Human)

Length

511 amino acids

AlphaFoldDB

AF-Q16322-F1-model_v4.pdb

Function

Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane;the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP

Sequence

MDVCGWKEMEVALVNFDNSDEIQEEPGYATDFDSTSPKGRPGGSSFSNGKILISESTNHETAFSKLPGDYADPPGPEPVVLNEGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLNKTNGGCSTEKSRK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Chronic Neutrophilic Leukemia and Chronic Leukemia

Location

Detected in kidney; in proximal tubules; glomerular endothelium; in vascular endothelium and in smooth muscle cells.

DOI ID

10.1006/geno.1997.4712; 10.1038/nature04727; 10.1101/gr.2596504; 10.1152/ajprenal.2000.278.6.f1013; 10.1152/ajprenal.00258.2001; 10.1097/01.asn.0000036866.37886.c5; 10.1126/science.1133427

RefSeq

NP_005540.1